Research studies show that metabolism is an important predictor of embryo viability. Author Study Year Gardner The role of glucose and pyruvate transport in regulating nutrient utilization by preimplantation mouse embryos. 1988 Brown The role of pyruvate, lactate and glucose during preimplantation development of embryos from F1 hybrid mice in vitro. 1991 Gardner Nutrient uptake and utilization can be used to select viable day 7 bovine blastocysts after cryopreservation. 1996 Thompson In vitro culture and embryo metabolism of cattle and sheep embryos – a decade of achievement. 2000 Gardner Embryo nutrition and energy metabolism and its relationship to embryo growth, differentiation, and viability. 2000 Swain Use of energy substrates by various stage preimplantation pig embryos produced in vivo and in vitro. 2002 Fernández-Gonzalez Long-term effect of in vitro culutre of mouse embryos with serum on mRNA expression of imprinting genes, development and behavior. 2004 Leese Embryo viability and metabolsm: obeying the quiet rules. 2007 Niakan Human preimplantation embryo development. 2012 Gardner Analysis of metabolism to select viable human embryos for transfer. 2013 Absalón-Medina Preimplantation embryo metabolism and culture systems: experience from domestic animals and clinical implications. 2014 Nasiri An Overview of The Available Methods for Morphological Scoring of Pre-Implantation Embryos in In Vitro Fertilization 2015